Lenka Besse Selected Research

azido- Phe- Leu- Leu- 4- aminomethyl- Phe- methyl vinyl sulfone

8/2015

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells.

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Lenka Besse Research Topics

Disease

15	Multiple Myeloma 01/2022 - 01/2015
8	Neoplasms (Cancer) 01/2022 - 08/2015
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022 - 10/2021
2	Hematologic Neoplasms (Hematological Malignancy) 01/2022 - 10/2017
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022
1	Plasma Cell Leukemia 01/2022
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2022
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 10/2021
1	Fibrosis (Cirrhosis) 01/2020
1	Hypoxia (Hypoxemia) 04/2018
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2018
1	Residual Neoplasm 10/2017
1	B-Cell Lymphoma (Lymphoma, B Cell) 08/2015

Drug/Important Bio-Agent (IBA)

10	Proteasome InhibitorsIBA 01/2022 - 08/2015
4	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2022 - 01/2018
4	Bortezomib (Velcade)FDA Link 10/2021 - 08/2015
3	Nelfinavir (Viracept)FDA Link 01/2021 - 01/2018
3	HIV Protease InhibitorsIBA 01/2021 - 01/2018
3	carfilzomibIBA 01/2021 - 08/2015
2	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2021
2	Pharmaceutical PreparationsIBA 10/2021 - 07/2021
2	Cell-Free Nucleic AcidsIBA 03/2020 - 10/2017
1	ProteomeIBA 01/2022
1	ixazomibIBA 10/2021
1	melflufenIBA 07/2021
1	Peptides (Polypeptides)IBA 07/2021
1	LipidsIBA 01/2021
1	Membrane LipidsIBA 01/2021
1	Phosphotransferases (Kinase)IBA 01/2020
1	LipopolysaccharidesIBA 01/2020
1	Axl Receptor Tyrosine KinaseIBA 01/2020
1	SphingomyelinsIBA 01/2019
1	Dexamethasone (Maxidex)FDA LinkGeneric 11/2018
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 04/2018
1	Transcription Factors (Transcription Factor)IBA 04/2018
1	Lopinavir FDA Link 01/2018
1	DNA (Deoxyribonucleic Acid)IBA 10/2017
1	Agammaglobulinaemia Tyrosine KinaseIBA 08/2015
1	ibrutinibIBA 08/2015
1	azido- Phe- Leu- Leu- 4- aminomethyl- Phe- methyl vinyl sulfoneIBA 08/2015
1	I-kappa B Proteins (I kappa B)IBA 08/2015
1	MicroRNAs (MicroRNA)IBA 01/2015
1	Circulating MicroRNAIBA 01/2015

Therapy/Procedure

3	Therapeutics 01/2021 - 01/2019